Neuropsychiatric symptoms in untreated Parkinson’s disease

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Neuropsychiatric symptoms in untreated Parkinson’s disease

Neuropsychiatric and cognitive symptoms are common in Parkinson's disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep diso...

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Neuropsychiatric symptoms in Parkinson's disease.

Neuropsychiatric symptoms are common in Parkinson's disease, even at the earliest stages, and have important consequences for quality of life and daily functioning, are associated with increased carer burden and increased risk for nursing home admission. In addition to cognitive impairment, a wide range of neuropsychiatric symptoms have been reported. In this article, the epidemiology, clinical...

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Neuropsychiatric Symptoms in Parkinson’s Disease: Beyond Complications

Parkinson's disease (PD) extends beyond movement to often encompass a range of psychiatric phenomena, such that it has been viewed as the prototypical neuropsychiatric disorder (1). While the movement disorder is primarily linked to a central dopamine deficit, neurodegenerative events in the main noradrenergic, serotoninergic, and cholinergic nuclei precede motor symptom onset, by a decade or l...

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Parkinson's disease--Part 3: Neuropsychiatric symptoms.

The nonmotor neuropsychiatric symptoms of Parkinson's disease, particularly depression, psychosis, and cognitive impairment/dementia, are major contributors to disability and a decline in quality of life. Their effect on patients may be more disabling than motor symptoms. Increasing awareness of the importance of recognizing and treating neuropsychiatric symptoms of this disease in the medical ...

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ژورنال

عنوان ژورنال: Neuropsychiatric Disease and Treatment

سال: 2017

ISSN: 1178-2021

DOI: 10.2147/ndt.s130997